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However, there are still challenges that need to be addressed, such as the optimization of properties, reliable characterization methods, safety evaluation, nanoparticles that might lead to unintended consequences like nano-pollution and cytotoxicity and regulatory aspects related to nanomedicines targeting skin cancer [176, 179]
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This is further supported by scRNA-seq results from our study, which show that many DEGs associated with immunity, cellular senescence, degenerative disease, or inflammation were significantly upregulated or downregulated in the model group but restored toward baseline in the WCV-treated group
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